邦妮-巴斯勒 分子生物学家

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Bonnie Bassler
Molecular Biologist | Class of 2002
Investigating the chemical signaling mechanisms that bacteria use to communicate with each other.

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Title
Molecular Biologist
Affiliation
Princeton University
Location
Princeton, New Jersey
Age
40 at time of award
Area of Focus
Genetics and Molecular Biology
Website
Bassler Lab
Princeton University: Bonnie Bassler
Published September 25, 2002
ABOUT BONNIE'S WORK
Bonnie Bassler is a molecular biologist investigating chemical signaling mechanisms that bacteria use to communicate with each other known as “quorum sensing.” Bassler identified the genetic and biochemical regulatory circuits that control this phenomenon, which was initially thought to be an unusual adaptation in a few species. Her work led to the discovery, by her and others, of similar mechanisms in a wide variety of species. Evidence collected to date has demonstrated that quorum sensing controls a broad range of activities, from bioluminescence to bacterial mating. Some bacteria compete with other species by interfering with their quorum sensing capacities. Others cooperate across species by using quorum sensing to produce complex structures such as biofilms, specialized protective arrangements of bacteria that in many ways parallel the early evolution of multicellular organisms 600 million years ago. Bassler has also identified important biomedical applications for quorum sensing; some bacteria use it to coordinate the secretion of toxins that, in smaller doses, would produce little or no ill effect. Developing medicines that block the quorum sensing activity may represent an important new strategy for treating bacterial infections. Thus, her research reveals new insights into the basic biology and ecology of bacteria, findings that may have direct application in the future treatment of disease.

BIOGRAPHY
Bonnie Bassler received a B.S. (1984) from the University of California, Davis and a Ph.D. (1990) from Johns Hopkins University. She was a post-doctoral fellow (1990–1993) and research scientist (1993–1994) at the Agouron Institute, La Jolla, California. In 1994, Bassler joined the faculty of the Department of Molecular Biology at Princeton, and she has been a faculty member of the Princeton Environmental Institute since 1996. The author of nearly thirty scholarly papers in journals such as Proceedings of the National Academy of Science (USA), Cell, Nature, and the Journal of Biological Chemistry, she also serves on the editorial board of several journals.

RECENT NEWS
Bonnie Bassler is a member of the National Academy of Sciences and the American Academy of Arts and Sciences. She is a Howard Hughes Medical Institute Investigator and the Squibb Professor and chair of the Department of Molecular Biology at Princeton University. Bassler’s research is paving the way to the development of novel therapies for combating bacteria by disrupting quorum-sensing-mediated communication. She received the Wiley Prize (2009), the Lounsbery Award (2011), and the L’Oreal-UNESCO award (2012) for her paradigm-changing scientific research and was made a member of the Royal Society and the American Philosophical Society in 2012. She sits on the National Science Board and was nominated to that position by President Barack Obama. The board oversees the National Science Foundation and prioritizes the nation’s research and educational priorities in science, math, and engineering.

Updated August 2015



邦妮-巴斯勒
分子生物学家 | 2002级
研究细菌用于相互交流的化学信号机制。

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标题
分子生物学家
工作单位
普林斯顿大学
工作地点
普林斯顿，新泽西
年龄
获奖时40岁
重点领域
遗传学和分子生物学
网站
巴斯勒实验室
普林斯顿大学。邦妮-巴斯勒
2002年9月25日发表
关于邦尼的工作
邦妮-巴斯勒是一名分子生物学家，研究细菌用来相互交流的化学信号机制，称为 "法定人数感应"。巴斯勒确定了控制这种现象的遗传和生化调节回路，这种现象最初被认为是少数物种的一种不寻常的适应。她的工作导致了她和其他人在多种物种中发现了类似的机制。迄今为止收集的证据表明，法定人数感应控制着广泛的活动，从生物发光到细菌交配。一些细菌通过干扰其他物种的法定人数感应能力与之竞争。其他细菌则通过利用法定人数感应来产生复杂的结构，如生物膜，这是细菌的专门保护性排列，在许多方面与6亿年前多细胞生物的早期进化相似。巴斯勒还发现了法定人数感应的重要生物医学应用；一些细菌利用它来协调毒素的分泌，而这些毒素在较小的剂量下会产生很少或没有不良影响。开发阻断法定人数感应活动的药物可能是治疗细菌感染的一个重要的新策略。因此，她的研究揭示了对细菌的基本生物学和生态学的新见解，这些发现可能直接应用于未来的疾病治疗。

个人简历
邦妮-巴斯勒在加利福尼亚大学戴维斯分校获得学士学位（1984年），在约翰-霍普金斯大学获得博士学位（1990年）。她曾在加州拉霍亚的Agouron研究所担任博士后研究员（1990-1993）和研究科学家（1993-1994）。1994年，巴斯勒加入普林斯顿大学分子生物学系，自1996年以来，她一直是普林斯顿环境研究所的教职员工。她在《美国国家科学院院刊》、《细胞》、《自然》和《生物化学杂志》等杂志上发表了近30篇学术论文，她还在一些杂志的编辑委员会任职。

最近的新闻
邦妮-巴斯勒是美国国家科学院和美国艺术与科学学院的成员。她是霍华德-休斯医学研究所的研究员，也是普林斯顿大学分子生物学系的斯奎布教授和主席。巴斯勒的研究正在为开发新的疗法铺平道路，通过破坏法定人数感应介导的通信来打击细菌。她因其改变模式的科学研究而获得威利奖（2009年）、卢斯贝里奖（2011年）和欧莱雅-联合国教科文组织奖（2012年），并在2012年成为英国皇家学会和美国哲学学会的成员。她是国家科学委员会的成员，由巴拉克-奥巴马总统提名担任该职位。该委员会负责监督国家科学基金会，并优先考虑国家在科学、数学和工程方面的研究和教育重点。

2015年8月更新