埃洛迪-格丁 寄生虫学家/病毒学家

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Elodie Ghedin
Parasitologist/Virologist | Class of 2011
Decoding the genomes of virulent human pathogens that cause such diseases as leishmaniasis, sleeping sickness, and river blindness and threaten the lives of millions in the developing world.


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Title
Parasitologist/Virologist
Affiliation
Department of Computational & Systems Biology, University of Pittsburgh School of Medicine
Location
Pittsburgh, Pennsylvania
Age
44 at time of award
Area of Focus
Microbiology, Virology, and Immunology
Published September 20, 2011
ABOUT ELODIE'S WORK
Elodie Ghedin is a biomedical researcher who is harnessing the power of genomic sequencing techniques to generate critical insights about human pathogens. Although the technology for obtaining nucleotide sequence data continues to accelerate, the labor-intensive task of analyzing and annotating the resulting data — for example, identifying genes, their functions, and their expression; determining the arrangement of genes within the genome; performing phylogenetic and functional comparisons with other known species — often lags behind. Ghedin has established herself as a leader of international projects that coordinate the efforts of scores of scientists to decode the function of some of the most virulent human pathogens. A major focus of her work has been parasites that cause diseases endemic to tropical climates, such as leishmaniasis, sleeping sickness, Chagas disease, elephantiasis, and river blindness. Through her direct research and mobilization of global scientific collaborations, Ghedin's work illuminates the similarities and differences in the molecular physiology of the various parasites, with important implications for targets for drug development. In addition, Ghedin and her colleagues are applying similar approaches to understanding viruses that infect humans. RNA viruses such as HIV and influenzae mutate particularly rapidly, making vaccine development difficult. In a high-resolution study of complete genome sequences of influenza A from thousands of isolates collected in the New York area, Ghedin and colleagues showed that the virus evolves with surprising rapidity even in a circumscribed geographic region. Through her contributions to parasitology and virology, Ghedin demonstrates that molecular genetics is not only essential for exploring the basic biology of pathogens but also represents a powerful tool in the hands of scientists working in coordination to improve public health across the globe.

BIOGRAPHY
Elodie Ghedin received a B.S. (1989) from McGill University, an M.S. (1993) from Université du Québec à Montréal, and a Ph.D. (1998) from McGill University. She was a postdoctoral fellow at the National Institute of Allergy and Infectious Diseases (1998-2000) and led the Viral Genomics group at the Institute for Genomic Research (2000-2006) prior to her appointment to the faculty of the University of Pittsburgh, where she is currently an assistant professor in the Department of Computational and Systems Biology and a member of the Center for Vaccine Research. She is also an associate investigator at the J. Craig Venter Institute. Her scientific articles have appeared in such publications as the Journal of Virology, Science, and Nature.

RECENT NEWS
Since 2014, Elodie Ghedin has been affiliated with New York University, where she is currently a professor in the Department of Biology and School of Global Public Health and affiliated with the Center for Genomics and Systems Biology.

Updated July 2015



埃洛迪-格丁（Elodie Ghedin
寄生虫学家/病毒学家 | 2011级
解密导致利什曼病、昏睡病和河盲症等疾病并威胁到发展中国家数百万人生命的毒性人类病原体的基因组。


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标题
寄生虫学家/病毒学家
工作单位
匹兹堡大学医学院计算与系统生物学系
工作地点
宾夕法尼亚州匹兹堡市
年龄
获奖时44岁
重点领域
微生物学、病毒学和免疫学
发表于2011年9月20日
关于Elodie的工作
Elodie Ghedin是一名生物医学研究人员，她正在利用基因组测序技术的力量来产生关于人类病原体的关键见解。尽管获取核苷酸序列数据的技术不断加速，但分析和注释所产生的数据的劳动密集型任务--例如，识别基因、其功能和表达；确定基因在基因组中的排列；与其他已知物种进行系统发育和功能比较--往往落后于人。格丁已经成为国际项目的领导者，这些项目协调了数十名科学家的努力，以解码一些最具毒性的人类病原体的功能。她工作的一个主要重点是引起热带气候特有疾病的寄生虫，如利什曼病、昏睡病、恰加斯病、象皮病和河盲症。通过她的直接研究和动员全球科学合作，格丁的工作阐明了各种寄生虫的分子生理学的相似性和差异性，对药物开发的目标有重要意义。此外，格丁和她的同事们正在应用类似的方法来理解感染人类的病毒。RNA病毒，如HIV和流感，变异特别快，使疫苗开发变得困难。在对纽约地区收集的数千个分离物的甲型流感完整基因组序列的高分辨率研究中，格丁和她的同事表明，即使在一个限定的地理区域内，该病毒也会以惊人的速度进化。通过她对寄生虫学和病毒学的贡献，格丁表明，分子遗传学不仅对探索病原体的基本生物学至关重要，而且也是科学家在协调工作以改善全球公共卫生方面的有力工具。

个人简历
Elodie Ghedin在麦吉尔大学获得学士学位（1989年），在魁北克大学蒙特利尔分校获得硕士学位（1993年），并在麦吉尔大学获得博士学位（1998年）。在被任命为匹兹堡大学教师之前，她是国家过敏和传染病研究所的博士后研究员（1998-2000年），并在基因组研究所领导病毒基因组学小组（2000-2006年），目前是计算和系统生物学系的助理教授和疫苗研究中心的成员。她也是J. Craig Venter研究所的副研究员。她的科学文章发表在《病毒学杂志》、《科学》和《自然》等刊物上。

最近的新闻
自2014年以来，埃洛迪-格丁一直隶属于纽约大学，目前她是该校生物系和全球公共卫生学院的教授，并隶属于基因组学和系统生物学中心。

2015年7月更新