管坤良 生物化学家

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Kun-Liang Guan
Biochemist | Class of 1998
Title
Biochemist
Location
Ann Arbor, Michigan
Age
35 at time of award
Area of Focus
Biochemistry, Biophysics, and Structural Biology
Website
Guan Lab
Published July 1, 1998
ABOUT KUN-LIANG'S WORK
Kun-Liang Guan is a biochemist whose work helps us understand how cells respond to changing conditions, such as infection and aging.

Guan studies a class of enzymes that act as molecular switches controlling the activity of other enzymes. Originally named for its function in immune cells, MAP kinase has since been shown to regulate many important cellular functions, including cell division and specialization. Guan has shown how these enzymes control normal physiologic processes and how viruses and bacteria interrupt normal functions, creating pathogenic effects. Papers authored and co-authored by Guan have appeared in publications such as the Journal of Biological Chemistry, Science, the Proceedings of the National Academy of Sciences USA, and Nature.

BIOGRAPHY
Guan is the Halvor Christensen Professor in Life Science and a professor of biological chemistry at the University of Michigan. After a postdoctoral fellowship (1989-91) at Purdue University, he became a lecturer (1991-92) and an assistant professor (1992-97) at the University of Michigan.

Guan received a B.S. (1982) from Hangzhou University, China, and a Ph.D. (1989) from Purdue University.

Last updated January 1, 2005



管坤良
生物化学家|1998级
职称
生物化学家
工作地点
密歇根州安阿伯市
年龄
获奖时35岁
重点领域
生物化学、生物物理学和结构生物学
网站
管坤良实验室
1998年7月1日出版
关于管坤良的工作
管坤良是一位生物化学家，他的工作帮助我们了解细胞如何对不断变化的条件作出反应，如感染和衰老。

管坤良研究一类作为控制其他酶活性的分子开关的酶。MAP激酶最初因其在免疫细胞中的功能而被命名，后来被证明可以调节许多重要的细胞功能，包括细胞分裂和专业化。管坤良已经表明这些酶如何控制正常的生理过程，以及病毒和细菌如何中断正常功能，产生致病作用。关晓彤撰写和与人合写的论文发表在《生物化学杂志》、《科学》、《美国国家科学院院刊》和《自然》等刊物上。

个人简历
管坤良是密歇根大学的Halvor Christensen生命科学教授和生物化学教授。在普渡大学做完博士后研究后（1989-91），他成为密歇根大学的讲师（1991-92）和助理教授（1992-97）。

管坤良在中国杭州大学获得学士学位（1982年），并在普渡大学获得博士学位（1989年）。

最后更新于2005年1月1日